Eduardo G. Moros, Ph.D., DABR

Professor and Director,

Division of Radiation Physics and Informatics

Phone: (501) 526-7474

_______________________________

Dr. Moros joined UAMS in August of 2005 from Washington University in St. Louis where he served as the Chief of the Hyperthermia Physics Service since 1991 and the Head of the Research Physics Section since 2001. He received his Ph.D. degree from the University of Arizona, Tucson, AZ, in 1990. Dr. Moros’ research interests are at the boundary of Physical/Engineering Sciences and Biomedical Sciences. He has developed several devices and systems to facilitate scientific testing of biomedical hypotheses in vitro (cell) and in vivo (live animals) with the ultimate aim of promoting translational research. His main interests are Radiation Oncology Physics, Thermoradiotherapy Physics/Engineering, ultrasound-based therapies and the application of thermal sciences to biomedical problems (thermal medicine). He is an active member of several scientific and professional societies and Past-President of the Society for Thermal Medicine.

Dr. Moros is an avid manuscript reviewer for many scientific journals and serves in the board of editors for several jounals.  He has also participated in many government grant review panels and was a regular member of the NIH Radiation Therapeutics and Biology (RTB) Study Section 2001-2005.

A. Education

University of Arizona, Tucson, AZ, B.S., 1984, Mechanical Engineering (with Distinction)

University of Arizona, Tucson, AZ, M.S.,1987, Mechanical Engineering

University of Arizona, Tucson, AZ, Ph.D.,1990, Mechanical Engineering

B. Professional Experience.

Academic Positions

1990 - 1991 Associate Researcher, Department of Human Oncology, University of Wisconsin-Madison, WI

1991 - 07/05 Chief, Hyperthermia Physics, Radiation Oncology, Washington University, St. Louis, MO

1991 - 1999 Assistant Professor, Department of Radiology, Washington University, St. Louis, MO

1999 - 2001 Associate Professor (tenured), Department of Radiology, Washington University, St. Louis, MO

2001 - 2004 Associate Professor (tenured), Dept Radiation Oncology, Washington University, St. Louis, MO

2003 - 07/05 Chief, Research Physics Section, Dept Radiation Oncology, Washington University, St. Louis

01/05 - 07/05 Professor (tenured), Department of Radiation Oncology, Washington University, St. Louis, MO

08/05 - 2005 Professor (tenured), Department of Radiation Oncology and Part-time Professor of Medical Dosimetry, University of Arkansas for Medical Sciences, Little Rock, AR.

Professional Memberships, Honors and Other Experience (Last five years)

9th International Congress on Hyperthermic Oncology, Co-chair and organizer, April 2004, St. Louis, MO.

International Association for Hyperthermic Oncology (IAHO), President, 2004-2008.

Society for Thermal Medicine (STM, formerly the North American Hyperthermia Society): Vice-President-Elect 2002-2003, President 2004-2005, Past-President 2005-2006, Physics Councilor 1997.

Medical Physics (Journal) Board of Editors, 2000 - 2007.

International Journal of Hyperthermia, Board of Editors, 2006 - pres.

Jounal of Applied Clinical Medical Physics, Board of Editors, 2007 - pres.

Radiation Therapeutics and Biology (RTB, formerly RAD) Study Section member, CSR, NIH, 2002-2005.

Active member: AAPM, ASTRO, ASME, BEMS, IEEE BME, STM (formerly NAHS), RRS.

Siteman Cancer Center faculty member at Washington University/Barnes-Jewish Hospital, 1997-2005.

Cancer Institute member at UAMS, Nov. 2005 – present.

C. Selected peer-reviewed publications from over 80.
Arthur RM, Trobaugh JW, Straube WL, Moros EG:  Noninvasive estimation of hyperthermia temperatures with ultrasound.  International Journal of Hyperthermia, peer-reviewed invited paper for a special issue on Non-Invasive Thermometry.  Sept 2005;21(6):589-600.

Whitehead TD, Brownstein BH, Parry JJ, Thompson N, Cha B, Moros EG, Rogers BE, Roti Roti JL:  Expression of the proto-oncogene Fos after exposure to radiofrequency radiation relevant to wireless communications.  Radiation Research, Oct 2005;164(4):420-430.

Novak P, Moros EG, Parry JJ, Rogers BE, Myerson RJ, Zeug A, Locke J, Rossin R, Welch MJ, Straube WL, Singh AK.  Experience with a Small Animal Hyperthermia Ultrasound System (SAHUS):  Report on 83 Tumors.  Physics in Medicine and Biology, Nov 2005;50(21):5127-5139.

Novak P, Moros EG, Straube WL and Myerson RJ:  SURLAS: Treatment delivery software for a new clinical grade ultrasound system for thermoradiotherapy – Safety controls and risk analysis.  Medical Physics, Nov 2005;32(11):3246-3256.

Arthur RM, Trobaugh JW, Straube WL, Moros EG:  Temperature dependence of ultrasonic backscattered energy in motion-compensated images.  IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Oct. 2005;52(10):1644-1652. (Electronic version includes movies of apparent motion of specimens due to temperature elevation).

Myerson RJ, Singh AK, Bigott HM, Cha B, Engelbach JA, Kim J, Lamoreaux WT, Moros EG, Novak P, Sharp TL, Straube WL, Welch MJ, Xu M:  Monitoring the effect of mild hyperthermia on tumor hypoxia by Cu-ATSM PET scanning.  International Journal of Hyperthermia, Mar. 2006;22(2):93-116.

Whitehead TD, Moros EG, Brownstein BH, Roti Roti JL:  Gene-expression does not change significantly in C3H 10T ½ cells after exposure to 847.74 CDMA or 835.62 FDMA radiofrequency radiation.  Radiation Research, 2006;165:626-635.

Whitehead TD, Moros EG, Brownstein BH, Roti Roti JL:  The number of genes changing expression after chronic exposure to Code Division Multiple Access or Frequency DMA radiofrequency radiation does not exceed the false-positive rate. Proteomics, 2006 Sep;6(17):4739-44.

Vanderwaal RP, Cha B, Moros EG, Roti Roti JL:  HSP27 phosphorylation increases after 45 degrees C or 41 degrees C heat shocks but not after non-thermal TDMA or GSM exposures.  International Journal of Hyperthermia, 2006 Sep;22(6):507-19. 

Pickard WF, Moros EG, Cha BA, and Novak P:  Electromagnetic and thermal characterization of an UHF-applicator for concurrent irradiation and high resolution non-perturbing optical microscopy of cells. Bioelectromagnetics, (web version available May 2006), 2006 Dec;27(8):593-601.

Shafirstein G, Hennings H, Kaufmann Y, Ferguson S, Novak P, Siegel E, Moros EG, Klimberg SV, Waner M, Spring P: Intraoperative conductive interstitial thermal therapy (CITT) to minimize local recurrence following tumor resection of early-stage breast cancer.  Technology Cancer Research Treatment, 2007 Jun;6(3):235-46.

Xu M, Myerson RJ, Xia Y, Whitehead T, Moros EG, Straube WL, Roti Roti JL: The effects of 41°C hyperthermia on the DNA repair protein, MRE11, correlate with radiosensitization in four human cell lines.  International Journal of Hyperthermia, 2007 Jun;23(4):343-352.

Peñagarícano J, Yan Y, Corry P, Moros EG, Ratanatharathorn V: Retrospective evaluation of pediatric cranio-spinal axis irradiation plans with the Hi-ART Tomotherapy system. Technology in Cancer Research and Treatment 2007; 6(4):355-360.

Shafirstein G, Novak P, Moros EG, Siegel E, Hennings L, Kaufmann Y, Ferguson S, Myhill J, Swaney M, Spring P: Conductive interstitial thermal therapy device for surgical margin ablation: In vivo verification of a theoretical model. International Journal of Hyperthermia, 2007; Sep 23(6):477-92.

Trobaugh JW, Arthur RM, Straube WL, Moros EG: A simulation model for ultrasonic temperature imaging using change in backscattered energy. Ultrasound in Medicine and Biology, 2008; Feb 34(2):289-298.  

Rao VS, Titushkin IA, Moros EG, Pickard WF, Thatte HS, Cho MR:  Nonthermal effects of radiofrequency-field exposure on calcium dynamics in stem cell-derived neuronal cells: elucidation of calcium pathways. Radiation Research, 2008; Mar 169(3):319-29.

Novák P, Peñagarícano JA, Nahirnyak V, Corry P, Moros EG:  Influence of the SURLAS applicator on radiation dose distributions during simultaneous thermoradiotherapy with helical tomotherapy.  Physics in Medicine and Biology, 2008 Apr 53(10):2509-2522.

D. Research Support

Ongoing Research Support

P01 CA104457 Roti Roti (PI at WUSTL)    07/01/04—06/30/09
NIH/NCI
UAMS Subcontract:  Radiosensitization by the Cellular Stress Response-Development of SAHUS-2 and Technical Support.  WUSTL Contract (PI: Roti-Roti): Technical and engineering aspects of the Small Animal Hyperthermia Ultrasound System (SAHUS) and the development of a second heating system (i.e., SAHUS-2).  Responsible for periodic maintenance, quality assurance procedures, training of new users, possible repairs, and thermal dosimetry analysis.  Manufacture, repair, and testing of applicators.  Development of ability to heat more than four tumors simultaneously through the development of SAHUS-2. 

Role:  UAMS Subcontract Principal Investigator

R01 CA CA107558 Arthur (PI at WUSTL)   07/01/05—06/31/08
NIH/NCI
3D Noninvasive Temperature Estimation with Ultrasound.
The aim of this research is to extend our methods of noninvasive temperature measurement using changes in backscattered ultrasound to three-dimensions and to test them in vivo animal models. Dr. Moros participation in this grant is being transferred to UAMS as a subcontract.
Role: Co-investigator/subcontractor.

ONR N00014-06-1-0100, Moros (PI)          10/07/05—09/30/08
Office of Naval Research
UAMS Subcontract: Heat Transfer Modeling of In Vitro Electromagnetic Applicators for Concurrent Optical Microscopy. UIC Contract (PI: Cho): Determination of Nociceptive Molecular Effects in Engineered Tissues in Response to Active Denial Type 94-GHz Irradiation.
Role: UAMS Subcontract Principal Investigator.

R21 CA108678  (Shafirstein)                     07/01/06-06/30/08

NIH/NCA                                                                  

Breast Tissue Ablation by Conductive Heating

Testing of new probes using conductive interstitial thermal therapy for the ablation of tumor tissue at the margins of breast cancer resections.  Hypotheses is that the use of conductive interstitial thermal therapy (CITT) can induce irreversible thermal damage in targeted tissue to destroy malignant tissue after primary tumor resection resulting in negative margins and decrease in the recurrence rate after lumpectomy.

Role:  Co-Investigator

Tobacco Research (Moros, executer)       07/01/2006-06/30/2009                 

Arkansas Master Tobacco Settlement and Arkansas Biosciences Institute                

Small Animal Conformal Radiation Therapy Device             

Development of a Small Animal Conformal Radiation Therapy Device that will provide a degree of geometric targeting comparable to what is routinely achievable in clinical radiotherapy using state-of-art technology in planning and dose delivery.

R01 CA44114 (Griffin)                              07/01/08-06/30/13                  

NIH/NCI                                                          

Physiological Factors in Hyperthermia

To find means to improve the efficacy of hyperthermia treatment of malignancy by exploiting differences in the physiological characteristics between tumors and normal tissues.

Role:  Co-Investigator