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SAHUS

Small Animal Hyperthermia Ultrasound System

An external ultrasound system has been developed for the heating of subcutaneously implanted tumors in small animals. This small animal hyperthermia ultrasound system (SAHUS) was designed to be compatible with a microPET scanner to facilitate studies of hyperthermia effects on tumor hypoxia. Collimation of thermal energy deposition, a specific goal for this device to avoid regional and/or systemic heating of small animals, was demonstrated thermometrically using thermoradiography following high-power short-time heating of a layered gel phantom. The system consisted of an acrylic applicator with up to four independent 5MHz non-focused ultrasound transducers, 10-channel RF generator, 16-channel thermocouple thermometer, and a PC with PID controller based power regulation software. The system is capable of performing a real time temperature feedback control of power deposited independently in each tumor, and simultaneously in up to four tumors at the time. The performance of the SAHUS was tested in over 90 experiments using 5 different cell-lines grown in thighs of female nude (nu/nu) mice. In vivo intratumoral temperatures were recorded during heating trials with interstitially implanted thermocouples. Compatibility with the microPET system was tested by carrying out PET imaging studies on the same tumor model before and during SAHUS induced hyperthermia. The SAHUS was able to produce hyperthermia in <10 mm diameter tumors to a target temperature of 41.5 °C, and maintained within a narrow temperature range (regulation error -0.02±0.10 °C) for up to 4 hours without significantly raising the core temperature of the animals. The concurrent operation of the SAHUS and the microPET did not show any interference.

The design and construction of SAHUS was supported by a grant from the US National Cancer Institute, R01 CA63121. The animal studies were supported by the following grants: R01 CA71638, CA104457, CA106587 and K08 CA88924.

Published papers:

P. Novak, E. Moros, J. Parry, B. Rogers, R. Myerson, A. Zeug, J. Locke, R. Rossin, W. Straube and A. K. Singh: Experience with a Small Animal Hyperthermia Ultrasound System (SAHUS): Report on 83 Tumors. Physics in Medicine and Biology, 2005; 50: pp 5127-5139.

J. Locke, A. Zeug, D. Thompson Jr., J. Allan, K. Mazzarella, P. Novak, D. Hanson, A. Singh, E. Moros and T. Pandita: Localized versus regional hyperthermia: comparison of xenotransplants treated with a small animal ultrasound and waterbath limb immersion. International Journal of Hyperthermia, 2005; 21(3): pp 271-281.

A. K. Singh, E. G. Moros, P. Novak, W. Straube, A. Zeug, J. E. Locke and R. J. Myerson: MicroPET-compatible, small animal hyperthermia ultrasound system (SAHUS) for sustainable, collimated and controlled hyperthermia of subcutaneously implanted tumours. International Journal of Hyperthermia, 2004;20(1): pp 32-44.

SAHUS highlinghts:

Diagram of SAHUS with applicator positioned in a microPET.

SAHUS controlling software.

University of Arkansas for Medical Sciences
Department of Radiation Oncology
4301 W. Markham St., Little Rock, AR 72205
Tel. (501) 686 7100, Fax (501) 686 7285

To Make an Appointment Call the Appointments Center at:
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For International Patient Appointments, Call 1-501-686-8071

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This page was edited on Tue Nov 28 09:40:41 CST 2006

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